The TissueCypher™ technology is quantitative and objective, which represents a significant improvement over standard histopathology, which is qualitative and subjective. The deep tissue interrogation provided by TissueCypher™ enables detection of multiple pathways associated with carcinogenesis, and multiple molecular and cellular changes that precede definitive morphologic changes. These changes include stromal changes such as infiltrating immune cells and angiogenesis, which play important roles in tumor development, but are not assessed by other technologies and tests in the Barrett’s space.