Delivering Spatial Biology
to the Clinic

Spatial biology is revolutionizing the discipline of pathology and the practice of medicine. Castle Biosciences is a pioneer in this field, using our spatial analytics platform for biologically aware AI to provide solutions across the precision medicine value chain from drug discovery to clinical diagnostics.

Our biologically aware AI platform delivered to the clinic the world’s first precision medicine test to predict the risk of developing esophageal cancer – one of the world’s most deadly cancers.

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Featured Webinars/Publications

Prediction of Progression in Barrett’s Esophagus Using a Tissue Systems Pathology Test: A Pooled Analysis of International Multicenter Studies

Iyer PG, Codipilly DC, Chandar AK, Agarwal S, Wang KK, Leggett CL, Latuche LR, Schulte PJ

Clinical Gastroenterolgy and Hepatology 2022


Spatialomics Delivered to the Clinic for Improved Health Outcomes in Barrett’s Esophagus

C Munroe

Munroe C, Hall M, Critchley-Thorne R

Journal of Precision Medicine 2022


Delivering clinically actionable information from tissue biopsies
is difficult.

Tissue systems:

  • are highly complex
  • are composed of many cell types and tissue structures
  • can have 1000x of active genes, transcripts and expressed proteins

Clinicians need new ways to analyze, interpret and report data.

Only this revolution can change clinical practice.

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Our TissueCypher® platform brings together key components of biologically aware AI.

Multiplex assay development

Library of fluorescent immunolabeling assays with robust SOPs for clinical use

Feature generation

Automatic extraction of cellular and molecular information while allowing user-directed generation of biologically relevant features

Model building & validation

Reduction of complexity, classifier development & validation through access to scarce tissue sources and clinical outcomes

Intellectual property

>30 issued patents covering spatially resolved analytical methods and first clinical assay